Role of Serum Amyloid A Protein in
Various Diseases with Special Reference
to Periodontal and Periapical
Inflammation- A Review
Published: December 1, 2020 | DOI: https://doi.org/10.7860/JCDR/2020/46072.14296
Syed Wali Peeran, Ahmed Elhassan, Mohammed Zameer, Syed Nahid Basheer, Mohammed Mustafa, Madhumala Thiruneervannan
1. Senior Registrar, Department of Dental, AF Hospital, Jizan, Chennai, Tamil Nadu, India.
2. Assistant Professor, Benghazi College of Dentistry, Benghazi University, Benghazi, Libya.
3. Department of Dentistry, Armed Forces Hospital, Jizan, KSA.
4. Department of Conservative Dental Sciences, College of Dentistry, Faculty of Dentistry, Jazan University, KSA.
5. Department of Conservative Dental Sciences, College of Dentistry, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
6. Department of Periodontics, VMS Dental College, Salem, India.
Correspondence
Dr. Syed Wali Peeran,
8, Ellis Road, Chennai, Tamil Nadu, India.
E-mail: doctorsyedwali@yahoo.in
Serum Amyloid A (SAA) is an Acute-Phase Protein (APP) produced as an innate nonspecific response to any tissue damage. Hence, it plays a significant role in chronic inflammatory diseases. In particular, SAA levels increase dramatically in chronic periodontitis and chronic apical periodontitis. Recent studies suggest this role of SAA in the pathogenesis of various diseases, including chronic periodontitis and chronic apical periodontitis. Thus, the focus of this review is to sum up the current understanding of the role of SAA in health and disease and to elaborate on possible mechanisms by which SAA could play a role in the pathogenesis of chronic periodontitis and chronic apical periodontitis.
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